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AUTOLOGOUS CONCENTRATED PLATELET-RICH PLASMA (A-ACR, c-PRP) CAN REJUVENATE THE FACE BY DERMAL BIOSTIMULATION.


REJUVENATION means to “ make someone or something look younger or lively” ( Oxford Paperback Dictionary and Thesaurus 2001).


Dorland’s Illustrated Medical Dictionary provides an excellent description of rejuvenation: “( L.juverescere- to become young): a renewal of youth or of strength and vigour”. So really it does not matter what cosmetic treatment you use. As long as the client in the salon looks younger, lively and shows signs of renewal of youth, strength of vigour, then you have achieved a goal in rejuvenation. This may be achieved by a facial, microdermabrasion, massage, cosmetic creams etc. So one does not have to purchase a painfully expensive laser of IPL device, that only really gives subtle and modest skin tightening changes and needs over-servicing with costly multiple applications of light over weeks. And the possibility of scarring is not excluded.


BRIEF OVERVIEW OF AUTOLOGOUS PLATELET-RICH PLASMA AND ACR

    • Platelet-rich derived growth factors play an important role in wound healing and the regeneration process.
    • Platelet rich plasma (PRP) is abbreviated as A-PRP or c-PRP.
    • Preparation in the side-room is possible as a high concentrate from plasma-rich plasma ( c-PRP) for clinical application
    • Concentrated PRP (c-PRP) can be generated from PRP
    • Platelet concentration in c-PRP is higher than the patients plasma
    • TGF-beta 1 can be checked in the c-PRP
    • Dermal rejuvenation is possible via autologous cellular regeneration (ACR). The process is referred to as ACR-PRP rejuvenation. The REGEN-PRP® KIT can be used for mesotherapy.
    • The REGENLAB®, ACR HARVESTING PROTOCOL consists of the following components: Special collection THT tubes, vena puncture, collection and harvest of blood into the THT tube ( 7 ml, venous blood), anti-coagulated whole blood, is carefully centrifuged to prevent platelet rupture, RBC and plasma and buffy coat is identified as well as the plasma layer containing A-PRP or C-PRP. The THT ACR-Tube is preferred to the Vacutainer® Tube, which is not authorized for therapeutic use.
 

ABBREVIATIONS:

  • PRP: Platelet- rich plasma

  • A-PRP: Autologous platelet-rich plasma

  • c-PRP : Concentrated platelet-rich plasma

  • PPP: Platelet-poor plasma

  • ACR: Autologous cellular regeneration


TABLE 1: Showing rejuvenation outcomes of beauty and cosmetic treatments. All treatments have positive outcomes but may vary in intensity and longevity. Some may need more treatments than others. Some last a while, others do nothing and waste the clients money.


OPTION

  • PRP

  • Microdermabrasion

  • Radio-frequency

  • Fraction. Laser

  • Mosaic laser

  • IPL

  • BOTOX

  • LED

  • Facial

  • Massage

  • Cosmetic creams

  • CO-2 Laser

  • Face lift

  • Vitamin A

TONE

 

TEXTURE

 


Complete rejuvenation of the aging human face is not achievable with currently available technologies such as RF, IPL, LED, biologicals or lasers. Aging is an irreversible process and cannot be slowed down. Partial short-term restoration of rejuvenation or preservation is indeed an outcome that can be achieved up to about the age of 60-years at which stage deep vertical and horizontal lines, sagging, wrinkles, discolouration and mid-face ptosis become a challenge to the aesthetician. At best, almost all beauty treatments render subtle and modest results over an extended period of time and need for repeated treatment .

SKIN ANALYSIS PRIOR TO PHOTO-LIGHT THERAPY, TONING, SKIN TIGHTENING OR ACR/PRP NON-ABLATIVE RESURFACING

Florence Barret-Hill (2004) has shown the importance of advanced skin analysis in the salon. This is needed to lend credibility to aesthetic medicine and to your salon/clinic. A comprehensive assessment is needed prior to IPL, RF, ACR/PRP and fractional photothermolysis because a failure to do so will invariably result in poor outcome and client dissatisfaction. Basing therapy on skin ultrasound analysis alone, results in poor measured outcomes. Because ultrasound alone of the dermis ignores the following important skin characteristics ( superficial anatomy) and elements:

  1. Texture (renewal and desquamation of the stratum corneum). Surface texture of the epidermis must be established in a consultation prior to therapy.

  2. Colour (abnormal production of melanin resulting in hyper- or hypopigmentation must be established).

  3. Secretion (acid mantle, sebaceous and sudiferous glands).Is the skin oily or dry? What is the lipid status?

Therefore, skin diagnostic devices , as used by BOLANDCELL, are needed and the following elements need to be established:

  1. Oilyness of skin

  2. Dryness of skin, pore status
  3. Melanin depth (dyschromia, lentigenes, sun-spots, telangiectasis, melanoma, freckles, melasma).
  4. Epidermal and dermal atrophy

Underlying structured damage induced by photo-aging. Ultrasound possibly can demonstrate dermal collagen, but is inconsistent on epidermal 3D morphology, skins secretions and elastin content ( elastosis).

WHAT WILL BE THE END-POINT OF YOUR REJUVENATION TREATMENT PLAN USING IPL, ACR/PRP , RF OR LASER?

Following your skin diagnostic analysis you may have to correct:

  1. Skin tone by tightening the skin. This takes time and many sessions are needed as well as maintenance therapy (RF, IPL, Aesthera®, E-max®, Titan®, Fraxel®). Correcting skin wrinkles is not a quick fix affair, and there is no magic bullet. The problem is variability of results or predictability, as the speed of progressive chronological skin aging differs from person to person, with different genetic backgrounds.

  2. Are you trying to correct the texture of the skin? Do you want to improve skin renewal and desquamation of the stratum corneum? Consider glycolic acid peels, microdermabrasion and light emitting diodes (LED) such as the light source provided by Omnilux® (distributed by Genop Healthcare™ in the RSA). In your rejuvenation endeavours you will be trying to improve excess keratinisation, loss of structural integrity leading jowls and sagging, especially of the lower face and mandibular areas, address loss of resiliency and adhesion (fibroblast and keratinocyte dysfunction) and improving glycation (see Barrett-Hill, 2004).
  3. Does your client present with skin colour problem (pigmentation, vitiligo, rosacea, telangiectasis grades 1-5, melasma, cloasma or lentignes)? You will be tested as most treatments give variable results in this category. This includes the use of IPL and fractional photothermolysis. No quick fix again. And recurrence of the pigment is possible, the moment the client is re-exposed to sunlight. So sunscreens, during and after photo-light therapy is critical. Melasma is tricky to treat and recurrence is common, especially in the hands of inexperienced doctors. This is also the case with freckles.
  4. Will you be treating combination of 1-3, including a secretion problem? Are you dealing with a deficient acid mantle, impaired lymphatic system, skin atrophy, thinning and acne? Will your treatment be directed at epidermal lipids, sebaceous or sudiferous secretions or restoration of glycosaminoglycans (see Barrett-Hill, 2004)?
  5. Do you think the skin disorder you are treating in front of you (i.e. photoaging, vertical and horizontal crepe lines, fine line, sagging of the chin, creasing of the décolleté), is permanent or temporary?
  6. What are your primary priorities? Do you want to treat the pigmentation, crowfeet wrinkles or vertical/horizontal crepe lines affecting the face, chin and décolleté? Or do you just treat? Both are testing areas for the therapist in the following respects. The dyschromia may well respond initially, but melasma will return. At best, whatever machine is used (IPL, LED or fractional laser), a 68.5% improvement in wrinkles will be detectible at 12 weeks. Mid-face ptosis is different to treat in persons older than 60-years. Skin tightening is not always easy to achieve, and it does not occur after only one treatment. Loss of structural (collagen) integrity will test the best of therapists, and often one has to resort to a filler. Botox after 60-years renders generally poor results, and money is wasted. Correction of the lymphatics with the structural integrity is important (see Barrett-Hill, 2004). Knowledge of all these elements, including background skin histology, is important so that your client can enjoy maximum response in the shortest possible time. Aspirations of the client must be determined and it may be required to tell them that it is only possible to achieve one level of improvement in the skin at the time. No guarantees can be given and multiple treatments (including maintenance therapy) are needed to give a gradual and subtle effect. In depth knowledge of ECM, glycosaminoglycans, skin histology and physiology and light physics is needed if one gets to get any results.


END-POINT ANALYSIS OF NON-ABLATIVE SKIN REJUVENATION: WHAT IS BEST FOR YOUR CLIENT?

You have to have a 1 hour consultation with the patient/client to determine visual analysis and consultation of skin. You must be trained in skin histology. Wide background experience is needed to prescribe rejuvenation options.

  • VISIA provides superior skin morphology analysis than ultrasound because it gives the therapist more data i.e. VISIA provides analysis of: spots, UV spots, melanin or brown spots, red areas ( malar cheek telangiectasis), wrinkles ( vertical and horizontal crepe lines including crow feet) , texture, pores and porphyrins. These epidermal and morphological features, critical to facial rejuvenation, are not available with current ultrasound devices. An alternative is the Beau Visage skin analysis system.

  • Ultrasound ( DERMASCAN) that can provide data on the dermal collagen status. Possibly 3D versions may overcome some of the drawbacks of the first generation models.
  • SD202 skin analyzer, as this provides excellent data on hydration, lipid, melanin, and erythema data at affordable prices and limited Salon budgets.
  1. Determine and exclude/identify skin disorders.

  2. Address important skin quality issues: colour (melanin), texture, and secretions.
  3. Grade pigmentation and wrinkles. Identify precancerous areas in clients with severe damage, and know about squamous cell carcinoma and melanomas. Are the naso-labial folds unsightly. Remember these lines are often the distinguishing features of great statesman.
  4. Check upper-lip creases/lines/folds/wrinkles. Assess crow-feet, and periorbital fine lines.
  5. Classify facial aging: Fitzpatrick grades/Glocau scores.
  6. Treat. Many sessions are needed, plus follow-up and maintenance therapy supported by quality creams some of which may be vitamin-A based. New developments include use of trophic factors and peptides in the moisturizers.

NEW FACIAL CELL THERAPY WITH AUTOLOGOUS CONCENTRATED PLATELET-RICH PLASMA (PRP) AVAILABLE IN AESTHETICS CLINICS IN SOUTH AFRICA. REGENLAB PROCESS.

REGENLAB-PRP PROCESS has now superseded the use of Isolagen®, as a leading biostimulatory method in South Africa to rejuvenate the aging face with the clients own enriched plasma. Cell-therapy for the for-seeable future is out. Isolagen® and Restorelle® technologies utilized the patients own cultured dermal fibroblasts to address facial wrinkles. Because of high production and transport costs, cell therapy with living fibroblasts became unaffordable, obsolete and production ceased. Restorelle® was initially championed at Stellenbosch. The hiatus left was filled by REGENLAB® PRP, a patented process, and the rejuvenation results have proven superior to those of Isolagen®. Another advantage is that REGENLAB® PRP is far cheaper, and can be generated in the doctors rooms within 30 minutes from a small blood specimen obtained from the client undergoing facial rejuvenation. Scientific testing of other A-PRP or c-PRP tubes have proved inferior to REGENLAB® Technology. Plain, unspecified tubes used off the shelf, and used in an uncontrolled fashion have shown pathetic platelet-yield and no measurable GF.

REGENLAB-PRP® PROCESS is state-of-the art technology, CE marked and provides the patient with the best enriched plasma, including platelet count and growth factor analysis. For the moment this is the best performance product and A-PRP technology available on the market, with predictable efficacy and measured outcomes. This has been verified by academic units and BOLANDCELL. This success has been enhanced with ongoing doctor-education in the use of A-PRP or c-PRP, including planned workshops, and hands-on training under supervision, country-wide. This initiative has been increased to ensure consistent results and to ensure patient safety.

REGENLAB-PRP® PROCESS” is a valuable and safe adjunct to attain cosmetic facial enhancement, by the biological route, one-off, with minimal risk and is popular for non-surgical skin rejuvenation. Many clients request to rejuvenate themselves with their own plasma, instead of traumatic thermal light, lasers, IPL and RF. These modalities, including fractional photo-thermolysis, are cost ineffective, require multiple passes over weeks and render invariable and non-lasting skin rejuvenation. In some clients scarring is a problem, together with post inflammatory hyper-pigmentation.

AVAILABILITY OF REGENLAB® PRP PROCESS REGARDING FACIAL REJUVENATION SERVICES IN SOUTH AFRICA

    • Cape Town, Cape Town City Bowl, Stellenbosch, Parklands
    • Sea Point
    • Durbanville, Bellville, Parow, Tyger-Waterfront, Strand, Somerset West
    • Gauteng, Johannesburg, Sandton, Randburg
    • Pretoria, Alberton
    • Port Elizabeth
    • Durban
    • Windhoek, Namibia

 

WHAT AUTOLOGOUS REGENLAB PRP® ( AUTOLOGOUS PLATELET RICH PLASMA) OFFERS REGARDING FACIAL REJUVENATION. “THE REGENLAB PROCESS”.

  • Quantifiable improvement of skin complexion with visible changes noticeable in 3-4 weeks-especially forehead, cheeks, neck and back of hands

  • A-PRP or c-PRP is not a volumetric filler, but biological cell therapy with your own cells and enriched plasma
  • Facial soft tissue augmentation without synthetic filler or animal products
  • No need for costly lasers, IPL, or RF
  • No need for fat transfer operations or face lifts
  • A popular, relatively painless injectable treatment for the aging face in cosmetic practices (like mesotherapy, except that A-PRP or c-PRP is used as the injectable, that is far more predictable)


HOW IS FACIAL AUGMENTATION AFFECTED WITH REGENLAB® A-PRP?

  • Augments the dermis and epidermis by enhancing the growth of keratinocytes, fibroblasts and deposition of collagen. This improves skin tone, texture and colour.

  • One-off treatment, negligible down time, A-PRP or c-PRP can ameliorate mild to moderate skin changes but needs redoing 6-12 monthly because of the ongoing chronological aging process and senescence of fibroblasts that eventually stall forming collagen and elastin due to age-exhaustion. Although very effective, the “REGEN PROCESS” is also non-permanent rejuvenation and maintenance treatment is needed to combat ongoing aging. There is no non-surgical procedure that can match the brilliant results of a facelift at 5 and 10 years. The “REGEN PROCESS” is an excellent adjunct to soft tissue facial rejuvenation but is not a magic bullet for the amelioration of deep creases, folds, pigmentation, elastosis, jowls and deep forehead vertical lines. Clients tend to forget the aging process continues unabated and that the results of non-invasive treatments such as laser, IPL and RF only last for about 6 months. The “REGEN PROCESS” does offer something special , because the patients are plasma is used for the enhancement of facial macro-aesthetics. The following areas on the face are selected for injection by the “REGEN PROCESS”:
  1. Forehead

  2. Glabella crease
  3. Malar and cheek area
  4. Periorbital and perioral zones ( including lower lid)
  5. Nasolabial and nasojugal folds


“REGEN PROCESS” OF FACIAL REJUVENATION WITH AUTOLOGOUS PLATELET-RICH PLASMA: PREFERRED METHOD OF A-PRP OR C-PRP DELIVERY TO SKIN DERMIS AND HYPODERMIS.

The “REGEN PROCESS”, by facial rejuvenation addresses the soft tissues lost through aging or solar damage – and is directed at improvement of dermal atrophy, fat atrophy, gravitational descent to a degree, loss of skin tone and skin texture. To be effective the activated and enriched plasma has to be injected into the skin and dermis by tiny and carefully directed needle jabs, much the same the way as other fillers and Botox® are delivered. The skin has to be numbed with topical anaesthetic cream ( Toppler®) and subcutaneous injection of local anaesthetic agent. This has to be done by a qualified doctor.

PRP can be delivered t o the anaesthetized skin ( Toppler®) by direct injection with a conventional hypodermic syringe and small bevelled needle. Allmake-up should have been removed prior to this procedure of skin biostimulation with PRP. The needle pricks in the skin are needed to kick-start the healing process of the A-PRP or c-PRP and proliferation of fibroblasts that will produce collagen needed to rejuvenate your skin. The process is slow and takes about 3 months , although good results are perceptible as early as 3 weeks. The rejuvenated fibroblasts last for a while and them succumb again to the inevitable chronological aging process and become tired. The complexion of the skin deteriorates and the lines and wrinkles sadly, reappear. So further injections will be needed , but the time period differs from client to client. Six monthly resurfacing is the experience of BOLANDCELL consultants. The crow-feet and marionette lines around the mouth are very difficult to control, regardless of the method used. REGENLAB PRP has to be administered by an accredited medical doctor or homeopath.

BOLANDCELL consultants are of the opinion that the best results of A-PRP or c-PRP are unquestionably when the PRP is delivered via a mesogun. Simply, more tiny patterned punctures are made under very controlled conditions. Initially the mesogun is set on manual and then on automatic that delivers magical amounts to the skin. The bevel of the needle can be accuratetly set to address the skin thickness of the lower lids, cheeks, forehead etc. Very consistent rejuvenation of the skin is achieved and far superior to those seen after fractional photothermolysis or other laser, or IPL treatments. A-PRP does not produce scarring that follows the use of lasers. Superior delivery of autologous platelet-rich plasma is accomplished by this technology because the depth of the needle can be accurately set.

INVARIABLE OR NO RESPONSE TO “THE REGEN” PROCESS OR ACR INCLUDE:

  • Alcohol abuse

  • Cigarettes
  • Genetics and rapid natural chronological aging with line formation
  • Advanced solar aging
  • Advanced hyperpigmentation
  • Advanced and irreversible facial changes: type iii and iv face
  • Deep vertical forehead lines
  • Telangiectasis of the cheeks and nose associated with plethora
  • Deep perioral lines ( marionette lines)
  • Persons with underlying systemic disorders

CONTRAINDICATIONS TO THE “REGEN PROCESS” OR ACR.

  • Facial cancer, past and present. This includes SCC, BCC and melanoma

  • Systemic cancer, chemotherapy, steroid therapy
  • Dermatological diseases affecting the face ( ie porphyria)
  • Blood disorders and platelet abnormalities
  • Anticoagulation therapy
  • Certain herbal products
  • Aspirin or anti-platelet agents
  • Platelet dysfunction syndrome, critical thrombocytopenia, hypofibrinogenaemia, haemodynamic instability, sepsis, acute and chronic infections, chronic liver disease, aspirin and possibly vitamin E consumption ( Source: REGEN LAB).

COST ANALYSIS OF THE “REGEN PROCESS”, FACIAL PRP, COMPARED TO OTHER TREATMENTS. CLIENT NEEDS TO BUDGET FOR COSMETIC AND AESTHETIC INTERVENTIONS.

  • Initial consultation: free

  • REGEN PROCESS ( TOTAL) : R3000Fraxel: R6000

  • Thermage R28000 (total)
  • Accent Alma RF: R 300
  • Botox: R1500 per 50 units inclusive of consultation and will do half of the face(every 4-6 months)
  • Facial in salon: R250 per treatment
  • Microdermabrasion: R 350 per treatment ( need 4-8 treatments)
  • LED phototherapy: R100 per treatment ( need 5-8 treatments)
  • Facelift: R 25000 ( one off)
  • Blepharoplasty: R10000 (one off)
  • Velashape/ Velasmooth/ Ultrashape: R 250 per treatment and 8-10 treatments are needed before any significant changes are visible
  • Advanced skin analysis: free


SAFETY OF THE REGEN PLASMA PROCESS OF FACIAL REJUVENATION WITH AUTOLOGOUS PLATELET-RICH PLASMA


It is safe treatment because autologous ( your own) plasma is used. Expect mild redness, swelling, bruising and minor discomfort.


HOW TO ENHANCE THE “REGEN PROCESS” OF FACIAL REJUVENATION WITH A-PRP MESOTHERAPY

  • Application of REGENPRP plus 4-6 sessions of LED in the doctors rooms

  • Avoid unrealistic add-on, “ nonsurgical face –lifts” approach to skin care
  • Avoid further sun exposure and use sun screens
  • Don’t be drowned in heavy moisturizers. Aging is not a lack of oil.
  • Consider conditioners containing glycolic acid
  • M-Active® night cream contains retinyl palmitate and is highly effective
  • Salon facial treatments for aging skin is essential on a regular basis ( weekly, then bi-weekly for 6-12 treatments), decreasing slowly to once or two over 4 weeks. Gentle massage is indIspensible.
  • Micro-currant in a salon can improve elasticity, collagen content and elastin content

MODUS OPERANDI OF THE REGEN PROCESS OF FACIAL REJUVENATION BY BIOSTIMULATION AND PRP MESOTHERAPY.

  • Step 1: Your doctor should do an advanced skin analysis , such at BOLANDCELL, that measures skin morphology and function that allows planning of treatment, and facilitates follow-up of the patented. Time: 30minutes. BOLANDCELL uses advanced academic skin technology to achieve these aims.

  • Step 2: Choose a doctor that you can trust. Discuss your concerns and problems.
  • Step 3: Have a positive outlook, and realistic goals. The aging process is an ongoing process and cannot be reversed despite what some doctors claim.. Some lesions on the face are very difficult to treat and recurrence is often seen by academic doctors. Some non-invasive apparatus and devices have no effect at all and waste time and money.
  • Step 4: The “REGEN PROCESS” has a very low side-effect profile because your own plasma is used. Tell the doctor about your allergies and pill intake ( also herbs!!)
  • Have treatment on a Friday and allow any selling to subside on the weekend
  • Remember not all rooms, doctors and labs provide optimum PRP.

THE “REGEN PROCESS”:

  1. Doctor takes a sample of venous blood from your arm

  2. Blood is placed in a special REGENLAB Collection Tube and the PRP is processed. Other tubes render inferior levels of PRP, and poor GF stimulation, with invariable facial rejuvenation or no response. Scientific publications confirm this as well as comprehensive assessment and quantification by BOLANDCELL. If any, unproven tubes are used, you will waste your time and money, because very poor quality PRP will be generated.
  3. PRP generation via the REGEN PROCESS takes 30 minutes in a side room and is an accepted process.
  4. Cover face with Toppler® or Emla® cream, or equivalent, a good 30-45 minutes before injection and the face must feel numb. Local anaesthesia may still be needed.
  5. Multiple small jab injections are made close together into the skin releasing the PRP in order to kick-start rejuvenation by GF stimulation that is derived from your platelets in the PRP. The neck and dorsums of the hands can also be done at one session. Procedure time for the face is about 1.5 hours.
  6. Recovery is fast and expect results at 3-4 weeks. Some persons show more swelling of the skin under the injections than other clients. It is impossible to identify who will show excessive swelling. Fortunetly, the swelling subsides in all and there are no sequelae. Marked improvement in your skin condition and your overall appearance can be expected.
  7. Adding sessions of LED ( non thermal red light) to THE REGEN PROCESS is in your interest and recommended. Daily application of M-ACTIV night cream or glycolic formulation ( Neostrata®) will enhance the results even more. So multimodal treatment with the light, creams, massage and the salon is important.
  8. Very acceptable and promising results have been reported from England, France and Japan and the longest follow up is about 2 years at the time of posting.


POTENTIAL SIDE-EFFECTS OF REGENLAB® ACR FACIAL MESOTHERAPY AND REJUVENATION

  • Intra-vascular injection ( thrombus)

  • Nerve trauma (very rare)

  • Haematoma/ bruising ( common , down-time 24-48 hours, and completely reversible)

  • Secondary infection ( very rare)

  • Peri-orbital swelling ( reversible in all cases)


BIOLOGICAL ROLE OF REGEN-LAB PLATELET-RICH PLASMA (A-PRP AND C-PRP) IN AESTHETIC MEDICINE TO CORRECT FACIAL WRINKLES AND AGING:

A-PRP ( C-PRP) MESOTHERAPY BY “THE REGEN PROCESS”:

Ameliorating facial wrinkles with IPL, RF, LED and non-ablative fractional resurfacing requires many interval treatments ( sometimes up to ten sessions), is labour intensive and results are usually modest and variable. Hyaluronic fillers are popular but very expensive for periorbital and perioral fine line rejuvenation , results are most often , short lived and skin granulomas forming lumps, are big draw backs. Non-invasive face rejuvenation devices are unable to affectively address, jowls, midface ptosis, sagging and creasing of the forehead and neck, such as a face lift. Autologous platelet-rich plasma (A-PRP or C-PRP) offers the patient a one-off biologic treatment that lasts for 6-8 months. Results from Japan, France, Chorea, Thailand, Europe, England and South Africa indicate that the aesthetic use of A-PRP ( REGEN-LAB®) is safe and efficacious. Reversible minor bruising, swelling and erythema may follow treatment with A-PRP. Enriched platelet–rich plasma is extracted from a centrifuged venous blood specimen (REGENLAB® blood collection tubes, supplied by Omnimed ( Pty)., Ltd, Randburg, Gauteng), as a side-room procedure and then injected intradermally/hypodermically to induce skin epidermal and dermal rejuvenation. A needle and syringe can be used manually, or the PRP can be inserted via a mesotherapy gun that works very well. This is achieved; cell biologically, by proliferation of fibroblasts and improvement of the ECM, including collagen deposition, by platelet-derived growth factors such as PDGF and TGF. Extensive quantification studies show that REGEN®-PRP through the process called autologous cellular regeneration ( REGEN/ACR/PRP) renders the highest platelet counts and biologically active growth factors such as PDGF, TGF and VEGF compared to other PRP purification devices. Our results show that the most responsive skin areas following PRP-mesotherapy, and the REGEN PROCESS, are the forehead and malar areas, with improvement of skin texture and tone. We can only speculate regards which GF plays the most important role in skin rejuvenation, and neocollaginization. All persons injected, by the “REGEN PROCESS or PRP-MESOTHERAPY”, respond subjectively with positive improvement of skin complexion. Perioral marionette lines are resistant to all forms of treatment including fillers, RF, IPL, and LED. The effects of PRP wear off at the 6 month mark. PRP does not improve pigmentation but acne scarring is responsive. The clinical results of PRP are better, more predictable and sustainable in our hands on scanning, than autologous cultured dermal fibroblast implantation, that has now lapsed into clinical unpopularity because of costs. PRP renders better results than hyaluronic filler on digital scanning. Best PRP response is in persons of either sex, with modest wrinkling and Glogau scores, in the age group 40-60 years. Post-PRP outcomes are enhanced by application of vitamin-A anti wrinkle creams or LED phototherapy on scanning. Advanced objective digital skin analysis post-PRP mesotherapy in our laboratory, shows quantitative improvement of wrinkle microrelief, skin biometrics, and epidermal morphology. This includes improvement of peak-trough amplitude and anisotropy/topography. Botox administered into the glabellar region can improve the results in young persons. PRP mesotherapy is a very valuable, affordable stand-alone or adjunctive biological skin treatment option, compared to RF, IPL, LASERS, rendering favourable epidermal rejuvenation as offered by aesthetic practitioners, with quantifiable measurable outcomes. Autologous cultured dermal fibroblasts for facial rejuvenation, once popular, has fallen into disfavour, because production is cost ineffective, inferior results compared to A-PRP alone, and the competitive availability of laser, RF, LED and IPL rejuvenation of the face. In some cases, non-invasive is futile when the client would benefit better from a face-lift or blepharoplasty.

REGENLAB/PRP DISTRIBUTOR IN THE RSA: Omnimed (Pty)., Ltd., Randburg, Gauteng. Tel: ( 011) 792-7120

REGEN LAB DETAILS: 5, rue de l’ eglise, 1146 Mollens VD, Switzerland. Internet details: www.regenlab.com., info@ regenlab.com.

Disclaimer. Bolandcell does no supply any cosmetic, aesthetic or therapeutic information regards rejuvenation treatment options. These must be discussed between the client and the resident health care professional/ aesthetician that is responsible for treatment options and outcomes.

BOLANDCELL ACADEMIC REFERENCES

  • Du Toit DF et al. Shoulder surgeon…. International Journal of Shoulder Surgery. 2007.1: 87-95. www.internationalshoulderjournal.org.

  • Du Toit DF et al. Soft and hard-tissue augmentation…. International Journal of Shoulder Surgery. 2007.1: 64-73. www.internationalshoulderjournal.org.
  • Man D et al. The use of platelet-rich plasma…. Plastic and Reconstructive Surgery. 107: 229-23. www.plasreconsurg.com
  • Marx RE et al. Platelet-rich plasma…..Oral Surgery, Ora lMedicine.. 1998:1. pt.wkhealth.com
  • Dugrillon A et al. Autologous concentrated platelet-rich plasma….. International Association of Oral and Maxillofacial Surgeons. 6 November 2002 on line. www.sciencedirect.com
    • Florence Barrett-Hill. Advanced Skin Analysis. 2004. Virtual Beauty Corporation ( recommended reading).

    • Mark Lees. Skin Care beyond the basics. Third Edition. Thompson, 2005

Posted 25 May 2008.

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Boland Cell - Cell Technology - Aesthetic Biotechnology