FIBROBLASTS 2009
HUMAN FIBROBLAST PARACRINE FUNCTION IN BEAUTY AESTHETIC COSMESIS
BOLANDCELL emphasizes the importance of fibroblast paracrine function in maintaining epidermal homeostasis and function of the epidermis. The skin remains the largest independent peripheral endocrine organ and important to the beauty industry. The paracrine functions of fibroblasts are important in maintenance of a smooth epidermis, reducing wrinkles and lines. These functions are complimentary after skin stimulation with lasers ( fractional or mosaic types), IPL and skin cosmetics ( Beauty Pacifique and M-Active). So human dermal fibroblasts play a central role in the dermal stromal microenvironment. The paracrine acting cytokine release from human skin cells facilitate:
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Keratinocyte proliferation and differentiation; regulation of keratinocyte activation
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Interaction with cutaneous dendritic cells (DC), allow differentiation and function and T-cell activation
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Facilitates a keratinocyte-fibroblast paracrine relationship and co-operative efforts
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Synthesis and degradation of fibrous and non-fibrous connective tissue matrix proteins
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Facilitate ICAM-1 expression and signalling of TNF- alpha.
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Fibroblast activation and increased immune modulation by further release of peptide growth factors, cytokines and inflammatory mediators. These regulate inflammation and immune responses
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Modulation of lymphocytes, macrophages, keratinocytes and dendritic cells
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Fibroblast and keratinocyte modulation of human melanocytes
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Fibroblast and keratinocyte basement membrane formation
IMPORTANT FIBROBLAST FUNCTIONS INCLUDE:
- Release of vasoactive substances: 5HT, histamine, prostaglandins
- Formation of extra cellular formation (ECM)
- Transformation to myofibroblasts: thus facilitating skin and wound contraction and enhancing wound healing
- Deposition of collagen and elastin ( collagen type IV., VII, and laminin 1)
- Fibroblasts are the principal source of entactin and nitrogen
Posted 8 September 2008
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