GROWTH FACTORS AND PEPTIDES AS REJUVENATION COSMETIC CREAMS
Ganong 2005, an eminent American physiologist divides growth factors (polypeptides and proteins) into three groups:
This group fosters the multiplication or development of various cells (i.e. Insulin -like growth factor, epidermal growth factor. Platelets or thrombocytes release platelet-derived growth factors ( PDGF, TGF, IGF,EGF, VEGF).
Cytokines are the second group and are produced by macrophages and lymphocytes. These are hormone-like molecules that act in a paracrine fashion to regulate immune responses( interleukins, interleukins I-13)
Colony-stimulating factors that regulate proliferation and maturation of red and white blood cells.
AUTOLOGOUS CELLULAR REGENERATION (ACR)-ADVANCE IN FACIAL REJUVENATION WITHOUT NEED FOR LIGHT RESURFACING
The ACR process in aesthetic /cosmetic medicine relies on the stimulation of resident mesenchymal and stem cells by platelet-derived growth factors. These are PDGF, TGF, IGF, EGF, and VEGF to mention a few. These are found in platelet-rich plasma (PRP) which is derived from centrifuged human blood. This PRP can be used to rejuvenate the aging face by multiple small injections directed at the skin dermis and hypodermis. Some use the term ACR-PRP-facial mesotherapy. The cosmetic or aesthetic practitioner can easily prepare it as REGENLAB-KIT is available in the RSA and distributed by Omnimed in Johannesburg . It is a good alternative to skin tightening with IPL and Laser and has almost no down time. Effects are visible after 3 weeks and the treatment lasts longer than 18 months. The treatment is safe and effective, but as one knows the aging clock with many wrinkles cannot be completely reversed. The growth factors present in PRP generated by the REGENLAB system is PDGF, TGF, IGF, and EGF AND VEGF. The effect is that dermal quality and texture is improved. The treatment is available in the RSA, England , Europe, Asia and Japan . An illustration is provided and you can look at the kit that is used to generate PRP from a specimen of your blood. Treatment is done in trained practitioners rooms and the costs are about R6000.So, in this example the GF's are delivered into the region of the facial wrinkles by tiny dermal injections.
GROWTH FACTORS NOW AVAILABLE IN COSMETIC CREAMS: NEW ADJUNCT TO VITAMIN-A AND SQUALENE. ANTI-WRINKLE CREAMS AND AND GROWTH FACTORS.
DERMAHEAL, a Korean company provide GF and peptide in a wide range of products. The manufacturer cites various functions:
- Removal of damaged skin cells
- Stimulation of skin and hair follicle proliferation
- Wrinkle amelioration and improvement of scar tissue
- Soothing of acne vulgaris
- Provides an anti-bacterial effect
- Prevents hair loss
- Revitalises skin and hair cells
The GF utilised in the DERMAHEAL range include EGF, basic Fibroblast Growth Factor, IGF, FGF, RRX, SOMATOTROPIN, and THYMOSIN-beta 4. The proclaimed benefits include improving the skin elasticity by upregulation of collagens, elastins, fibronectins, and hyaluronic acids.
The mimicking peptides used in DERMAHEAL include, IDP2, IDP5, COPPER PEPTIDE, EDP3, CTP, ASP, TGP-2, IDP2, Alopectin and Retardrin. The products are nano-encapsulated allowing skin penetration and absorption. The cytokines and growth factor molecules are contained within the nanosomes. Other ingredients are rejuvenating amino acids, minerals, proteases, anti-oxidants and multi-vitamins.
- Ganong WF. Review of Medical Physiology. Lange , New York , 2005
- Du Toit et al: Shoulder surgeon and autologous cellular regeneration. IJSS 2007, 1: 87-95 ( Available on Google search engine).
REGENLAB PRP/ACR: BEFORE FACIAL REJUVENATION
REGENLAB PRP/ACR: AFTER BIOLOGICAL FACIAL REJUVENATION
REGENKIT FOR PRP/ACR AND FACIAL MESOTHERAPY